| Pair Name | Curcumin, Olaparib | ||
| Phytochemical Name | Curcumin (PubChem CID: 969516 ) | ||
| Anticancer drug Name | Olaparib (PubChem CID: 23725625 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Curcumin, Olaparib | |||
| Disease Info | [ICD-11: 2B66.Z] | Oral cancer | Investigative | |
| Biological Phenomena | Inhibition-->Chromatin remodeling | |||
| Gene Regulation | Down-regulation | Expression | PARP1 | hsa142 |
| Down-regulation | Expression | CHD1L | hsa9557 | |
| Down-regulation | Expression | H3C1 | hsa8350 | |
| Down-regulation | Expression | EP300 | hsa2033 | |
| In Vitro Model | H357 | Tongue squamous cell carcinoma | Homo sapiens (Human) | CVCL_2462 |
| Result | The present study reveals that Cur + Ola treatment increased oral cancer cell death not only through catalytic inhibition of PARP-1 but also predominantly through PARP-1 trapping and indirect inhibition of chromatin remodeling. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Olaparib enhances curcumin-mediated apoptosis in oral cancer cells by inducing PARP trapping through modulation of BER and chromatin assembly. DNA Repair (Amst). 2021 Sep;105:103157. doi: 10.1016/j.dnarep.2021.103157. | Click |
